Publication

CMOS-Compatible Biosensing Platform for Multiplexed Lactate and PH Monitoring in Low-Volume Biosamples

Mihai Adrian Ionescu
2025

Abstract

This work presents a novel multi-marker sensor platform integrating a silicon nanowire (SiNW) junctionless field-effect transistor (JLFET)-based pH sensor and an amperometric lactate sensor on a single chip, fabricated using a CMOS-compatible top-down process. Real-time, multiplexed detection of lactate and pH is demonstrated using a multichannel electrochemical readout integrated circuit. The platform delivers reliable sensing in low-volume samples as small as 15 μl, offering current sensitivities of 51 μA/mM/cm2 for lactate and 18 nA/pH for pH, while showing negligible crosstalk. The reported results underscore the platform's potential for compact, wearable biosensing applications that harness system-on-chip technology to enable continuous, real-time multi-biomarker monitoring in serum or interstitial fluid, paving the way for personalized healthcare and disease management.

Official source

https://infoscience.epfl.ch/entities/publication/f6380596-8e27-4c73-9962-8acc31f7634c

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Mihai Adrian Ionescu
2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f6380596-8e27-4c73-9962-8acc31f7634c

About this result

Related concepts (32)

Extracellular fluid

In cell biology, extracellular fluid (ECF) denotes all body fluid outside the cells of any multicellular organism. Total body water in healthy adults is about 60% (range 45 to 75%) of total body weight; women and the obese typically have a lower percentage than lean men. Extracellular fluid makes up about one-third of body fluid, the remaining two-thirds is intracellular fluid within cells. The main component of the extracellular fluid is the interstitial fluid that surrounds cells.

System on a chip

A system on a chip or system-on-chip (SoC ,ˈɛsoʊsiː; pl. SoCs ,ˈɛsoʊsiːz) is an integrated circuit that integrates most or all components of a computer or other electronic system. These components almost always include on-chip central processing unit (CPU), memory interfaces, input/output devices, input/output interfaces, and secondary storage interfaces, often alongside other components such as radio modems and a graphics processing unit (GPU) – all on a single substrate or microchip.

Body fluid

Body fluids, bodily fluids, or biofluids, sometimes body liquids, are liquids within the human body. In lean healthy adult men, the total body water is about 60% (60–67%) of the total body weight; it is usually slightly lower in women (52–55%). The exact percentage of fluid relative to body weight is inversely proportional to the percentage of body fat. A lean man, for example, has about 42 (42–47) liters of water in his body.

Related publications (1)

CMOS-Compatible Biosensing Platform for Multiplexed Lactate and PH Monitoring in Low-Volume Biosamples

Chat with Graph Search

Structuration of micro-fluidic devices based on low temperature co-fired ceramic (LTCC) technology