Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

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Preventing the misfolding or aggregation of transactive response DNA binding protein with 43 kDa (TDP-43) is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis and other neurodegenerative diseases. In this work, we ...

TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...

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Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

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Microsecond Time-Resolved Cryo-Electron Microscopy

Structural study of nickelate based heterostructures

Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

Method of preparation of amyloidogenic protein aggregates and uses thereof

Revealing the Mechanism Underlying 3D-AFM Imaging of Suspended Structures by Experiments and Simulations

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

Trio preserves motor synapses and prolongs motor ability during aging

Composition and Element Distribution Mapping of γ′ and γ" Phases of Inconel 718 by High-Resolution Scanning Transmission Electron Microscopy and X-ray Energy-Dispersive Spectrometry

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

Deconstructing and Reconstructing the Complexity of Tau pathology

In Situ and Time-Resolved Transmission Electron Microscopy of Nanoscale Processes

A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

Near-atomic resolution reconstructions from in situ revitrified cryo samples

Towards near-atomic resolution imaging of microsecond nanoscale dynamics

Multidimensional Electron Imaging of Catalyst Layer Materials

Stable Ta2O5 nanotubes decorated by PbS by the SILAR method for photocatalytic dye degradation

Discontinuous Galerkin methods for Fisher-Kolmogorov equation with application to a-synuclein spreading in Parkinson's disease

De novo designed proteins: a study in engineering novel folds and functions