Publication

8-Methoxyisoquinoline derivatives through ortho-selective metalation of 2-(3-methoxyphenyl)ethylamine

Manfred Schlosser
1991
Journal Articles

Abstract

Butyllithium in Et2O smoothly metalates 3-MeOC6H4CH2CH2NHCOCMe3 at the ortho position flanked by the two substituents. Subsequent reaction with DMF followed by acid catalyzed cyclization and redn. gives 8-methoxy-1,2,3,4-tetrahydroisoquinoline (I). [on SciFinder (R)]

Official source

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