Publication

Catalytic Friedel-Crafts Reaction of Aminocyclopropanes

Jérôme Waser, Florian Patrick Marie Daniel De la Barre De Nanteuil
2013
Journal Articles

Abstract

A Lewis acid catalyzed Friedel-Crafts reaction between donor-acceptor aminocyclopropanes and indoles and other electron-rich aromatic compounds is reported. Indole alkylation at the C3 position was generally obtained for a broad range of functional groups and substitution patterns. In the case of C3-substituted indoles, C2 alkylation was observed. The reaction gives a rapid access to gamma amino acid derivatives present in numerous bioactive molecules.

Official source

https://infoscience.epfl.ch/entities/publication/f3f4776e-c085-464c-a8c7-471eac2f8384

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Catalytic Friedel-Crafts Reaction of Aminocyclopropanes

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