Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

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The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I interferons ...

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

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Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

The role of eosinophils in breast cancer

m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

A Manganese Phosphate Nanocluster Activates the cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

Human genomics of the humoral immune response against polyomaviruses

The Drosophila Baramicin polypeptide gene protects against fungal infection

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Enhancing T-cell response in cancer immunotherapy using nanoparticles

cGAS regulation and activity during genotoxic stress

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers