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The possibility to simulate the properties of many-body open quantum systems with a large number of degrees of freedom (d.o.f.) is the premise to the solution of several outstanding problems in quantum science and quantum information. The challenge posed by this task lies in the complexity of the density matrix increasing exponentially with the system size. Here, we develop a variational method to efficiently simulate the nonequilibrium steady state of Markovian open quantum systems based on variational Monte Carlo methods and on a neural network representation of the density matrix. Thanks to the stochastic reconfiguration scheme, the application of the variational principle is translated into the actual integration of the quantum master equation. We test the effectiveness of the method by modeling the two-dimensional dissipative XYZ spin model on a lattice.