Publication

Resolving Cellular Morphology in the Human Brain with Multiparametric Diffusion MR Spectroscopy

2025

Abstract

Diffusion-weighted magnetic resonance spectroscopy (dMRS) is a unique, non-invasive technique capable of probing cell-type specific morphology. However, conventional dMRS methods are limited in their ability to provide detailed morphological information. This study demonstrates the potential of a multi-parametric dMRS approach, combining diffusion-time dependent and double-diffusion encoding MR spectroscopy, to characterize soma and neurite morphology of neuronal and glial cells. This methodology holds promise for developing biomarkers for the diagnosis, monitoring, and phenotyping of neurological pathologies, like Alzheimer's Disease, Parkinson's Disease, or Multiple Sclerosis, where alterations in soma and neurite morphology are reported.

Official source

https://infoscience.epfl.ch/entities/publication/f1cc7510-c3c9-4353-94e2-aa536b683799

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2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/f1cc7510-c3c9-4353-94e2-aa536b683799

About this result

Related concepts (28)

Glia

Glia, also called glial cells (gliocytes) or neuroglia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system that do not produce electrical impulses. The neuroglia make up more than one half the volume of neural tissue in our body. They maintain homeostasis, form myelin in the peripheral nervous system, and provide support and protection for neurons. In the central nervous system, glial cells include oligodendrocytes, astrocytes, ependymal cells and microglia, and in the peripheral nervous system they include Schwann cells and satellite cells.

Radial glial cell

Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia, including astrocytes and oligodendrocytes. Their cell bodies (somata) reside in the embryonic ventricular zone, which lies next to the developing ventricular system. During development, newborn neurons use radial glia as scaffolds, traveling along the radial glial fibers in order to reach their final destinations.

Glial scar

A glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system. In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects.

Related publications (8)

Resolving Cellular Morphology in the Human Brain with Multiparametric Diffusion MR Spectroscopy

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