Publication

The Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds

Xile Hu, Oleg Vechorkin
2010
Journal Articles

Abstract

A general and straightforward protocol for the cross-coupling of non-activated alkyl halides with heterocyclic CH bonds has been developed. The transformation is chemo- and regioselective and many functional groups on both coupling partners are tolerated. The method employs cheap nickel/copper catalysts, and expands significantly the scope of CH functionalization.

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The Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds

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