Publication

Room temperature C(sp(2))-H oxidative chlorination via photoredox catalysis

Xile Hu, Lei Zhang
2017
Journal Articles

Abstract

Photoredox catalysis has been developed to achieve oxidative C-H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp(2))-H bonds over C(sp(3))-H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.

Official source

https://infoscience.epfl.ch/entities/publication/f02f1ad5-e318-4bdb-89c1-7f28bcff0268

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Room temperature C(sp(2))-H oxidative chlorination via photoredox catalysis

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