Publication

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Li Tang
2024
Journal Articles

Abstract

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.

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Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

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