Publication

Engineering of extracellular matrix proteins : Integrin specific fibronectin fragment for mesenchymal stem cells differentiation and design of fibronectin-laminin fusion protein

2008
Student Projects

Abstract

[...] This project focuses on specific α5β1 integrin (α5β1) activation, because its crucial roles in differentiation and in adhesion have already been studied. The project is articulated in two related parts. The first and main one is dedicated to specific α5β1 activation with the goal of controlling cell differentiation. The second and minor part focuses on the engineering of a fusion protein capable of activating both receptors simultaneously if close enough. [... click on "Download fulltext" for full abstract]

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2008
Student Projects

Abstract

Official source

Related concepts (27)

Cellular differentiation

Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover.

Stem cell

In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type.

Adult stem cell

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells. Scientific interest in adult stem cells is centered around two main characteristics.

Related publications (1)

Engineering of extracellular matrix proteins : Integrin specific fibronectin fragment for mesenchymal stem cells differentiation and design of fibronectin-laminin fusion protein

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Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III