Publication

A miniaturized monolayer trough with variable surface area in the square-millimeter range

Horst Arthur Vogel
1998
Journal Articles

Abstract

A new simple concept for a miniaturized monolayer trough is described. The overall monolayer area in the expanded state is approx. 150 mm2 and can be reduced by a factor of 2. The surface area is a function of the shape of the meniscus formed by the subphase and is controlled by the amt. of water in the monolayer trough. The controlled compression of monolayers to a desired area per mol. with simultaneous observation of the lateral distribution of fluorescently labeled mols. is shown. A biol. reaction between a specific antibody and lipid anchored peptide demonstrates the feasibility of monolayer expts., which require only very small quantities of substance (in the pmol range). This trough might also be a valuable tool for the 2D crystn. of proteins at lipid layers via specific binding sites such as metal chelators. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/ee3db949-b18f-4041-be92-5e03cc6652b1

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Horst Arthur Vogel
1998
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ee3db949-b18f-4041-be92-5e03cc6652b1

About this result

Related concepts (29)

Surface area

The surface area (symbol A) of a solid object is a measure of the total area that the surface of the object occupies. The mathematical definition of surface area in the presence of curved surfaces is considerably more involved than the definition of arc length of one-dimensional curves, or of the surface area for polyhedra (i.e., objects with flat polygonal faces), for which the surface area is the sum of the areas of its faces. Smooth surfaces, such as a sphere, are assigned surface area using their representation as parametric surfaces.

Lipid bilayer

The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around all cells. The cell membranes of almost all organisms and many viruses are made of a lipid bilayer, as are the nuclear membrane surrounding the cell nucleus, and membranes of the membrane-bound organelles in the cell. The lipid bilayer is the barrier that keeps ions, proteins and other molecules where they are needed and prevents them from diffusing into areas where they should not be.

Monolayer

A monolayer is a single, closely packed layer of atoms, molecules, or cells. In some cases it is referred to as a self-assembled monolayer. Monolayers of layered crystals like graphene and molybdenum disulfide are generally called 2D materials. A Langmuir monolayer or insoluble monolayer is a one-molecule thick layer of an insoluble organic material spread onto an aqueous subphase in a Langmuir-Blodgett trough. Traditional compounds used to prepare Langmuir monolayers are amphiphilic materials that possess a hydrophilic headgroup and a hydrophobic tail.

Related publications (1)

A miniaturized monolayer trough with variable surface area in the square-millimeter range

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Biologically addressable monolayer structures formed by templates of sulfur-bearing molecules