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Publication

Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow

Michele De Palma, Florent Philippe Maurice Duval
2019
Journal Articles

Abstract

Macrophages modulate tumor response to chemotherapy; in this issue, Lossos and colleagues show that high-dose alkylating agents instigate a synthetic lethal program in lymphoma cells that is independent of DNA damage and involves recruitment and priming of macrophages for antibody-mediated tumor phagocytosis. These fi ndings implicate chemotherapy-elicited macrophages as critical effectors of lymphoma clearance during biological therapy.

Official source

https://infoscience.epfl.ch/entities/publication/ec9526ec-2a4f-4cb4-97cf-37a4e37eb7eb

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Michele De Palma, Florent Philippe Maurice Duval
2019
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ec9526ec-2a4f-4cb4-97cf-37a4e37eb7eb

About this result

Related concepts (29)

T-cell lymphoma

T-cell lymphoma is a rare form of cancerous lymphoma affecting T-cells. Lymphoma arises mainly from the uncontrolled proliferation of T-cells and can become cancerous. T-cell lymphoma is categorized under Non-Hodgkin lymphoma (NHL) and represents less than 15% of all Non-Hodgkin's diseases in the category. T-cell lymphomas are often categorised based on their growth patterns as either; aggressive (fast-growing) or indolent (slow-growing).

Lymphoma

Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). The name typically refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night. Many subtypes of lymphomas are known.

Macrophage

Macrophages (abbreviated as Mφ, MΦ or MP) (large eaters, from Greek μακρός (makrós) = large, φαγεῖν (phagein) = to eat) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. This process is called phagocytosis, which acts to defend the host against infection and injury.

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Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow

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