Optical manipulation and detection of biological particulates are crucial procedures in biophotonics. Optical sectioning (OS) opens the avenue to three-dimensional (3D) microscopy, but nonoptical approaches, including sample adhesion and mechanical scannin ...
American Association for the Advancement of Science (AAAS)2025
Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, afflict tens of millions of patients worldwide. They are characterized by protein aggregation and progressive neuronal loss, leading to cognitive and motor impairments, and ult ...
Latest advances in super-resolution microscopy allow the study of subcellular features at the level of single proteins, which could lead to discoveries in fundamental biological processes, specifically in cell signaling mediated by membrane receptors. Desp ...
Centrioles are evolutionarily conserved microtubule-based organelles essential for cell division, ciliogenesis, and cell polarity. While centrioles are critical for many cellular processes, their selective elimination is crucial during specific development ...
Molecular behavior can change dramatically at interfaces, and these changes become even more pronounced when molecules are confined within nanoscale dimensions. In living organisms, nanoscale channels play a crucial role in selectively transporting molecul ...
The distribution of geometrically necessary dislocation (GND) densities is critical to understanding the heterogeneous plastic deformation at intragranular scales in polycrystals. In this work, we performed an in situ electron backscatter diffraction (EBSD ...
The specific and covalent labeling of the protein HaloTag with fluorescent probes in living cells makes it a powerful tool for bioimaging. However, the irreversible attachment of the probe to HaloTag precludes imaging applications that require transient bi ...
Optical Projection Tomography (OPT) imaging provides isotropic resolution for samples up to a few millimeters. High resolution OPT is achieved by deconvolving Focal-Plane-Scanning (FPS-OPT) data but it requires to accurately know the system's Point Spread ...
