Investigating the molecular basis of ligand binding to and activation of olfactory receptors in living cells

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Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

Compound of the general formula (Ia), (Ib) and (Ic) R50 and R60 are different form each other and are selected from the group consisting of -R70, -ZR70, -Z-OH, -Z-NH2, -Z-SH, -Z-OC(O)R70, -OC(O)R70, - COOH and its corresponding salts, -C(O)NH2, -C(O)NH-R70 ...

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplet ...

The arise of disagreement is an emergent phenomenon that can be observed within a growing social group and, beyond a certain threshold, can lead to group fragmentation. To better understand how disagreement emerges, we introduce an analytically tractable m ...

Injection molding is known to create a layered anisotropicmorphologyacross the sample thickness due to varying shear and cooling ratesduring the manufacturing process. In this study, scanning small-angleX-ray scattering was used to visualize and quantify t ...

Owing to the advancements in the area of power electronics, efficient and flexible ac to dc conversion is made possible, bringing back into focus the idea of the dc power transmission at various voltage levels. Several technical and economical factors advo ...

We revisit the problem max-min degree arborescence, which was introduced by Bateni et al. [STOC'09] as a central special case of the general Santa Claus problem, which constitutes a notorious open question in approximation algorithms. In the former problem ...

Local and global inference methods have been developed to infer structural contacts from multiple sequence alignments of homologous proteins. They rely on correlations in amino acid usage at contacting sites. Because homologous proteins share a common ance ...

The response of simple plasmonic nanorods to polarized illumination is studied in detail. Depending on the orientation of that polarization with respect to the symmetry axes of the nanostructure, a chiral response can occur, which can be analyzed through a ...

Metal ions, such as Na+, Mg2+, Ca2+, and Zn2+, are highly abundant in biological systems. For many G protein-coupled receptors (GPCRs), metal ions, especially Na+, have been found to stabilize the receptors' inactivate state preventing receptor activation. ...

We report the functionalization of cysteine residues with lipophilic alkynes bearing a silyl group or an alkyl chain using amphiphilic ethynylbenziodoxolone reagents (EBXs). The reactions were carried out in buffer (pH 6 to 9), without organic co-solvent o ...

Investigating the molecular basis of ligand binding to and activation of olfactory receptors in living cells

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De novo designed proteins: a study in engineering novel folds and functions

Biobased surfactants

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Disagreement and fragmentation in growing groups

Scanning Small-Angle X-ray Scattering of Injection-Molded Polymers: Anisotropic Structure and Mechanical Properties of Low-Density Polyethylene

On Energy Control of Modular Multilevel Converters

Better Trees for Santa Claus

Impact of phylogeny on structural contact inference from protein sequence data

Polarization-Controlled Chromo-Encryption

The role of metal ions in G protein-coupled receptor signalling and drug discovery

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water