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Metal-bearing and trifluoromethyl-substituted pyrimidines: generation and functionalization

Related publications (31)

Parametric Reduced Order Model of a Gas Bearings Supported Rotor

Jürg Alexander Schiffmann, Fabio Nobile, Dimitri Maurice Goutaudier

Gas bearings use pressurized gas as a lubricant to support and guide rotating machinery. These bearings have a number of advantages over traditional lubricated bearings, including higher efficiency in a variety of applications and reduced maintenance requi ...

2023

RE:SLAB — a load bearing system for open-ended component reuse in building structures

Dario Redaelli, Corentin Jean Dominique Fivet, Jan Friedrich Georg Brütting, Alex-Manuel Muresan, Edisson Xavier Estrella Arcos

The construction industry plays a major role in the high levels of greenhouse gas emissions, resource consumption, and waste generation observed nowadays. Key to the circular economy, structural component reuse arises as a promising solution to divert cons ...

2024

Multiscale Spatiotemporal Characterization of Embodied Environmental Performance of Building Structures in Geneva from 1850 to 2018

Corentin Jean Dominique Fivet, Catherine Elvire L. De Wolf, Serena Vanbutsele

Load-bearing systems in buildings, significant in material use and embodied greenhouse gas emissions (EGHGE), have lacked detailed analysis on their environmental and functional relationships over time and space. This study evaluates the environmental impa ...

2024

Novel Alkynylation Methods through the Combination of Hypervalent Iodine Reagents and Alkynyl-trifluoroborate Salts

Julien Aymeric Borrel

The alkyne motif is a versatile functional group often encountered in organic chemistry. It can be involved in various transformations such as the alkyne-azide cycloaddition and has found widespread application in medicinal chemistry, chemical biology and ...

EPFL2024

Influence of model uncertainty and long term deformations in action effects calculation in reinforced concrete structures

Xhemsi Malja

Most codes of practice adopt a semi probabilistic design approach for the dimensioning and assessment of structures. Accordingly, structural safety is ensured by performing limit state verifications using design values determined with adequately calibrated ...

EPFL2024

Technosignatures Longevity and Lindy's Law

Claudio Grimaldi

The probability of detecting technosignatures (i.e., evidence of technological activity beyond Earth) increases with their longevity, or the time interval over which they manifest. Therefore, the assumed distribution of longevities has some bearing on the ...

Iop Publishing Ltd2024

Parametric Reduced Order Model of a Gas Bearings Supported Rotor

Jürg Alexander Schiffmann, Fabio Nobile, Dimitri Maurice Goutaudier

Amer Soc Mechanical Engineers2023

Robust Design of Herringbone Grooved Journal Bearings using Multi-Objective Optimization with Artificial Neural Networks

Jürg Alexander Schiffmann, Soheyl Massoudi

Herringbone grooved journal bearings (HGJBs) are widely used in micro-turbocompressor applications due to their high load-carrying capacity, low friction, and oil-free solution. However, the performance of these bearings is sensitive to manufacturing devia ...

2023

Robust Design of Herringbone Grooved Journal Bearings using Multi-Objective Optimization with Artificial Neural Networks

Jürg Alexander Schiffmann, Soheyl Massoudi

Amer Soc Mechanical Engineers2023

Graph neural networks for dynamic modeling of roller bearings

Olga Fink, Vinay Sharma

Machine learning has paved the way for the real-time monitoring of complex infrastructure and industrial systems. However, purely data-driven methods have not been able to learn the underlying dynamics and generalize them to operating conditions that have ...

PHM Society2023

An Integrated Approach to Designing Robust Turbocompressors on Gas Bearings Through Surrogate Modeling and Constrained Multi-Objective Optimization

Jürg Alexander Schiffmann, Cyril Picard, Soheyl Massoudi

Designing turbocompressors is a complex and challenging task, as it involves balancing conflicting objectives such as efficiency, stability, and robustness against manufacturing deviations. This paper proposes an integrated design methodology for turbocomp ...

ASME Amer Soc Mechanical Engineers2023

Interactive design with optimum matchmaking of reused structural elements – a software implementation

Corentin Jean Dominique Fivet, Jan Friedrich Georg Brütting, Jonas Warmuth

Structural systems are a significant contributor to buildings’ embodied carbon and reusing structural elements in new load-bearing applications is one strategy to reduce this impact. However, integrating this approach into existing design workflows without ...

International Association for Shell and Spatial Structures (IASS)2023

Mechanics, Modeling, and Upscaling of Biocemented Soils: A Review of Breakthroughs and Challenges

Lyesse Laloui, Dimitrios Terzis, Ray Harran

Biogeotechnical research has inspired revolutionary ideas to claim the status of a distinctive branch of geotechnical engineering. Most notably, underground carbonate mineralization, most commonly referred to as microbially induced carbonate precipitation ...

ASCE-AMER SOC CIVIL ENGINEERS2023

Exploring the potential of the critical shear crack theory for reinforced and post-tensioned glass beams: Initial analysis and experiments

Alain Nussbaumer, Pieter Christian Louter, Jagoda Cupac

In the evolution of structural glass beam elements, the requirements for post-fracture load bearing capacity and safe failure behaviour have led to the development of reinforced and post-tensioned beams. Maximum bending capacity in the post-fracture state ...

2023

Synthesis and application of bifunctional hypervalent iodine reagents for peptide modification

Elija Grinhagena

Protein-protein interactions (PPIs) are responsible for regulating many biological processes in human bodies. PPIs often have a large binding site and often interact through an alpha helical segment. Therefore, the inhibition of PPIs can be difficult using ...

EPFL2023

BamX: Rethinking Deployability in Architecture through Weaving

Mark Pauly, Yingying Ren, Tian Chen, Seiichi Eduardo Suzuki Erazo, Stefana Parascho

Deployable gridshells are a class of planar-to-spatial structures that achievea 3D curved geometry by inducing bending on a flat grid of elastic beams. However, theslender nature of these beams often conflicts with the structure’s load-bearing capacity.To ...

De Gruyter2023

Hypervalent Iodine: New Reagents and Functionalization of Peptides

Eliott Hugo Joran Le Du

Alkynes are found in a multitude of natural or synthetic bioactive compounds. In addition to the capacity of these chemical motifs to impact the physicochemical properties of a molecule of interest, the well-established reactivity of alkynes makes them ide ...

EPFL2023

Low-tech methods for the reuse of reinforced concrete structural elements

Maléna Bastien Masse, Julie Rachel Devènes, Corentin Jean Dominique Fivet, Nicole Widmer

Most of existing buildings are made of concrete, new buildings are being built with it and others are demolished when still in good structural condition. This drives increased demands for raw materials, greenhouse gas emissions, and an accumulation of demo ...

2023

Triple Crossed Flexure Pivot Based on a Zero Parasitic Center Shift Kinematic Design

Simon Nessim Henein, Etienne Frédéric Gabriel Thalmann

Thanks to their absence of play, absence of contact friction and possible monolithic fabrication, flexure pivots offer advantages over traditional bearings in small-scale, high accuracy applications and environments where lubrication and wear debris are pr ...

2022

Reinforcing hydrogels with in situ formed amorphous CaCO3

Michael David Kessler, Huachuan Du, Esther Amstad, Matteo Hirsch, Ran Zhao, Tianyu Yuan

Hydrogels are often employed for tissue engineering and moistening applications. However, they are rarely used for load-bearing purposes because of their limited stiffness and the stiffness-toughness compromise inherent to them. By contrast, nature uses hy ...

ROYAL SOC CHEMISTRY2022