Publication

Peptide engineering: a trimeric \"locked-in\" zinc finger motif

1999
Conference Papers

Abstract

A symposium report. The concept of template assembled synthetic proteins (TASP) has been evaluated for the locked-in fold derived from the DNA-binding bba zinc finger motif based on the consensus sequence Xaa3-Cys-Xaa2-4-Cys-Xaa12-His-Xaa3-4-His-Xaa4 to mimic some structural and functional features. [on SciFinder (R)]

Official source

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1999
Conference Papers

Abstract

Official source

Related concepts (7)

Protein engineering

Protein engineering is the process of developing useful or valuable proteins through the design and production of unnatural polypeptides, often by altering amino acid sequences found in nature. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles. It has been used to improve the function of many enzymes for industrial catalysis. It is also a product and services market, with an estimated value of $168 billion by 2017.

Synthetic biology

Synthetic biology (SynBio) is a multidisciplinary field of science that focuses on living systems and organisms, and it applies engineering principles to develop new biological parts, devices, and systems or to redesign existing systems found in nature. It is a branch of science that encompasses a broad range of methodologies from various disciplines, such as biotechnology, biomaterials, material science/engineering, genetic engineering, molecular biology, molecular engineering, systems biology, membrane science, biophysics, chemical and biological engineering, electrical and computer engineering, control engineering and evolutionary biology.

Artificial gene synthesis

Artificial gene synthesis, or simply gene synthesis, refers to a group of methods that are used in synthetic biology to construct and assemble genes from nucleotides de novo. Unlike DNA synthesis in living cells, artificial gene synthesis does not require template DNA, allowing virtually any DNA sequence to be synthesized in the laboratory. It comprises two main steps, the first of which is solid-phase DNA synthesis, sometimes known as DNA printing. This produces oligonucleotide fragments that are generally under 200 base pairs.

Related publications (4)

Peptide engineering: a trimeric \"locked-in\" zinc finger motif

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