Publication

Continuous Arterial Spin Labeling of Mouse Cerebral Blood Flow Using an Actively-Detuned Two-Coil System at 9.4T

2011
Conference Papers

Abstract

Among numerous magnetic resonance imaging (MRI) techniques, perfusion MRI provides insight into the passage of blood through the brain's vascular network non-invasively. Studying disease models and transgenic mice would intrinsically help understanding the underlying brain functions, cerebrovascular disease and brain disorders. This study evaluates the feasibility of performing continuous arterial spin labeling (CASL) on all cranial arteries for mapping murine cerebral blood flow at 9.4T. We showed that with an active-detuned two-coil system, a labeling efficiency of 0.82 +/- 0.03 was achieved with minimal magnetization transfer residuals in brain. The resulting cerebral blood flow of healthy mouse was 99 +/- 26mL/100g/min, in excellent agreement with other techniques. In conclusion, high magnetic fields deliver high sensitivity and allowing not only CASL but also other MR techniques, i.e. H-1 MRS and diffusion MRI etc, in studying murine brains.

Official source

https://infoscience.epfl.ch/entities/publication/e85b2655-208d-4ca7-8455-249526aae46a

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2011
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/e85b2655-208d-4ca7-8455-249526aae46a

About this result

Related concepts (31)

Perfusion

Perfusion is the passage of fluid through the circulatory system or lymphatic system to an organ or a tissue, usually referring to the delivery of blood to a capillary bed in tissue. Perfusion may also refer to fixation via perfusion, used in histological studies. Perfusion is measured as the rate at which blood is delivered to tissue, or volume of blood per unit time (blood flow) per unit tissue mass. The SI unit is m3/(s·kg), although for human organs perfusion is typically reported in ml/min/g.

Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

Neurological disorder

A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. There are many recognized neurological disorders, some relatively common, but many rare. They may be assessed by neurological examination, and studied and treated within the specialities of neurology and clinical neuropsychology.

Related publications (9)

Continuous Arterial Spin Labeling of Mouse Cerebral Blood Flow Using an Actively-Detuned Two-Coil System at 9.4T

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