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Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota

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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

Dario Neri

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadly type of cancer, with an extremely low five-year overall survival rate. To date, current treatment options primarily involve various chemotherapies, which often prove ineffecti ...

Springer Science and Business Media LLC2025

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Johan Auwerx, Olaia Maria Naveiras Torres-Quiroga, Frédérica Schyrr, Charles Christopher Bataclan

Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During agin ...

SPRINGERNATURE2023

Probing the importance of valency and spatial organization of immune regulator PD-1 with DNA-based nanomaterials

Maartje Martina Cornelia Bastings, Alice Comberlato, Cem Tekin, Kaltrina Paloja, Jorieke Weiden

WILEY2021

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

Johan Auwerx, Kristina Schoonjans

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with dysregulation of liver metabolism and inflammation. G-protein coupled bile acid receptor 1 (TGR5) is a cell surface receptor that is involved in multiple metabolic pathways. How ...

2021

Mechanical Immunoengineering of T-cells for Therapeutic Applications

Li Tang, Armand Kurum, Kewen Lei

T cells, a key component in adaptive immunity, are central to many immunotherapeutic modalities aimed at treating various diseases including cancer, infectious diseases, and autoimmune disorders. The past decade has witnessed tremendous progress in immunot ...

American Chemical Society2020