Publication

Systematic design of a targeted organometallic antitumor drug in pre-clinical development

Paul Joseph Dyson
2007
Journal Articles

Abstract

Organometallic ruthenium compds. that are effective anticancer and antimetastasis agents are currently under intensive investigation (see also the article by Peter Sadler in this issue). This article provides a personal account of the way in which we have exploited the different properties of the organoruthenium (and osmium and rhodium) compds. to rival traditional DNA-binding platinum drugs, culminating in the discovery of a non-classical mol. that is in an advanced stage of pre-clin. evaluation.

Official source

https://infoscience.epfl.ch/entities/publication/e78c8c00-5911-468d-8f73-6a11cabf2d89

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