Publications related to Rapid Production of Submicron Drug Substance Particles by Supersonic Spray Drying

Cavitation bubble dynamics and microjet atomization near tissue-mimicking materials

Mohamed Farhat, Armand Baptiste Sieber, Davide Bernardo Preso

In recent years, considerable interest has been devoted to the interactions between cavitation bubbles and tissue-mimicking materials due to their promising applications in medicine and biomedical sciences. The strong fluid-structure interaction between a ...

AIP Publishing2023

Estrogen receptor signaling in the human breast epithelium

Céline Berthe Constantin

Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...

EPFL2022

Comparative study between Cubic and Ellipsoidal Fokker-Planck kinetic models

Mohammadhossein Gorji

Motivated by improving the performance of particle-based Monte-Carlo simulations in the transitional regime, Fokker–Planck kinetic models have been devised and studied as approximations of the Boltzmann collision operator. By generalizing the linear drift ...

2019

Two-fluid plasma model for radial Langmuir probes as a converging nozzle with sonic choked flow, and sonic passage to supersonic flow

Philippe Frédérique Bruno Guittienne, Alan Howling, Ivo Furno

Using the Lambert function, Guittienne et al. [Phys. Plasmas 25, 093519 (2018)] derived two-fluid solutions for radial Langmuir probes in collisionless and isothermal plasma. In this Brief Communication, we point out the close analogy with classical compre ...

American Institute of Physics (AIP)2019

The Investigation of Flory-Huggins Interaction Parameters for Amorphous Solid Dispersion Across the Entire Temperature and Composition Range

Esther Amstad

Amorphous solid dispersion (ASD) is one of the most promising enabling formulations featuring significant water solubility and bioavailability enhancements for biopharmaceutical classification system (BCS) class II and IV drugs. An accurate thermodynamic u ...

2019

Measurements of ion velocity and wave propagation in a hollow cathode plume

The mechanism responsible for the production of energetic ions in the plume of hollow cathodes for electric propulsion is still an open issue. These ions are of concern to cathode and thruster lifetime, particularly for cathodes operating at high (>20 A) d ...

IOP PUBLISHING LTD2019

A Continuation Multi Level Monte Carlo (C-MLMC) method for uncertainty quantification in compressible inviscid aerodynamics

Pénélope Leyland, Fabio Nobile, Michele Pisaroni

In this work we apply the Continuation Multi-Level Monte Carlo (C-MLMC) algorithm proposed in Collier et al. (2014) to efficiently propagate operating and geometric uncertainties in inviscid compressible aerodynamics numerical simulations. The key idea of ...

Elsevier2017

The Role of Impeller Outflow Conditions on the Performance of Vaned Diffusers

Jürg Alexander Schiffmann

Highly loaded impellers, typically used in turbocharger and gas turbine applications, exhaust an unsteady, transonic flow that is nonuniform across the span and pitch and swirling at angles approaching tangential. With the exception of the flow angle, conf ...

American Society of Mechanical Engineers2017

Impact of rotating and fixed nozzles on vortex breakdown in compressible swirling jet flows

Leonhard Kleiser, François Gallaire

Vortex breakdown of swirling, round jet flows is investigated in the compressible, subsonic regime by means of Direct Numerical Simulation (DNS). This is achieved by solving the compressible Navier-Stokes equations on a cylindrical grid using high-order sp ...

Elsevier2016

NANOPARTICLES Production of amorphous nanoparticles by supersonic spray-drying with a microfluidic nebulator

Esther Amstad

Amorphous nanoparticles (a-NPs) have physicochemical properties distinctly different from those of the corresponding bulk crystals; for example, their solubility is much higher. However, many materials have a high propensity to crystallize and are difficul ...

American Association for the Advancement of Science2015

Characterization of the Flow Generated in an Annular Test Facility

Peter Ott, Elia Colombo, Dominique Charbonnier, Cécile Deslot

Annular cascades are particularly useful to study the three dimensional phenomena encountered in turbomachines. The Non-Rotating Annular Test Facility of the Swiss Federal Institute of Technology in Lausanne (EPFL) consists in a radial-axial inlet nozzle a ...

2011

Investigation on the Three-Dimensional Flow Mechanisms in Annular Axial Compressor Cascades for Aero Engines with Flow Control by Aspiration on the Hub and on the Blades

Elia Colombo

The axial compressor is an essential component of aero-engines and gas turbines. This work investigates how flow control by aspiration applied to the hub and to the blades of axial compressor wheels can improve the static pressure rise by preventing detrim ...

EPFL2011

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song, Hui Yang

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

Interaction between a surface dielectric barrier discharge and transonic airflows

Samantha Pavon

The use of plasmas in aerodynamics has become a recent topic of interest. The potentialities of different types of plasmas are being investigated for low velocity and high velocity flow control, as well as for plasma-assisted combustion. Dielectric barrier ...

EPFL2008

The gas flow rate increase obtained by an oscillating piezoelectric actuator on a micronozzle

Jürgen Brugger

Micronozzles with piezoelectric actuator were fabricated and investigated. The micronozzles were fabricated in glass substrates using a powderblasting technique, and the actuator is a bimorph structure made from a piezoelectric polymer. The actuator was lo ...

2008

Numerical and experimental investigation of the shock-vane interaction in a transonic compressor

Stefan Kristukat

A numerical and experimental investigation of the shock-IGV (inlet guide vane) interaction in a transonic compressor is conducted at the Laboratoire de Thermique Appliquée et de Turbomachines (LTT) at the Ecole Polytechnique Fédérale de Lausanne (EPFL). Th ...

EPFL2008

Hydrodynamics of the free surface flow in Pelton turbine buckets

Alexandre Perrig

The design of Pelton turbines has always been more difficult than that of reaction turbines, and their performances lower. Indeed, the Pelton turbines combine 4 types of flows: (i) confined, steady-state flow in the piping systems and injector, (ii) free w ...

EPFL2007

Effects of high-speed airflows on a surface dielectric barrier discharge

Christoph Hollenstein, Pénélope Leyland, Peter Ott, Samantha Pavon

A detailed study of the interaction between high-speed gas flows and surface dielectric barrier discharges (DBD) is presented. In the present paper, it is demonstrated that a DBD can be sustained in transonic airflows, up to isentropic Mach numbers of 1.1. ...

2007

Inclusion of aerodynamic non-equilibrium effects in supersonic plasma jet enthalpy probe measurements

Malko Gindrat, Christoph Hollenstein

Low pressure plasma spraying (LPPS) is a thermal spraying technique that has found a niche for low oxidation products. It uses a low pressure environment (i.e:, chamber pressure between 2 and 90 kPa) and yields supersonic plasma jets. The enthalpy probe te ...

2005