Publications related to An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer

Related publications (6)

Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

Background We propose a new approach for designing personalized treatment for colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical modeling of the results. ...

BMC2023

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Luqing Li, Michele De Palma, Nahal Mansouri, Ali Ghasemi, Alan Nicolas Thierry Guichard, Yahya Mohammadzadeh, Bruno Torchia

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical re ...

Nature Portfolio2023

Computer-Assisted Diagnosis of Lymph Node Metastases in Colorectal Cancers Using Transfer Learning With an Ensemble Model

Jean-Philippe Thiran

Screening of lymph node metastases in colorectal cancer (CRC) can be a cumbersome task, but it is amenable to artificial intelligence (AI)-assisted diagnostic solution. Here, we propose a deep learning-based workflow for the evaluation of CRC lymph node me ...

ELSEVIER SCIENCE INC2023

Conditional Separable Effects

Mats Julius Stensrud, Aaron Leor Sarvet

Researchers are often interested in treatment effects on outcomes that are only defined conditional on posttreatment events. For example, in a study of the effect of different cancer treatments on quality of life at end of follow-up, the quality of life of ...

2022

Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma

Paul Joseph Dyson

Simple Summary In this study, drug combination screening was used to design a multidrug combination consisting of repurposed drugs to treat sunitinib-resistant clear cell renal cell carcinoma. In the frame of this project, the multidrug combination has bee ...

MDPI2021

Fluorescence-Based and Fluorescent Label-Free Characterization of Polymer Nanoparticle Decorated T Cells

Demetri Psaltis, Harm-Anton Klok, Ahmed Bassam Sayed Ayoub Mohamed Emam, Tanja Thomsen

Cells are attractive carriers for the transport and delivery of nanoparticulate cargo. The use of cell-based carriers allows one to enhance control over the biodistribution of drug-loaded polymers and polymer nanoparticles. One key element in the developme ...

American Chemical Society2021