Dissecting the mechanisms of centriole stability in Caenorhabditis elegans: Focus on SAS-1

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Optical manipulation and detection of biological particulates are crucial procedures in biophotonics. Optical sectioning (OS) opens the avenue to three-dimensional (3D) microscopy, but nonoptical approaches, including sample adhesion and mechanical scannin ...

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, and Huntington's, afflict tens of millions of patients worldwide. They are characterized by protein aggregation and progressive neuronal loss, leading to cognitive and motor impairments, and ult ...

Embryogenesis is a complex process that starts from a single-cell fertilised egg and ends with a completely formed embryo. During embryo development, tissues are formed, patterned, and matured to create a fully functional organism. Central to these process ...

Signaling centers are specialized groups of cells that release morphogens, guiding the fate and behavior of adjacent cells during morphogenesis. For instance, the apical-ectodermal-ridge (AER) in developing limbs, is crucial for coordinating cell fate and ...

Molecular behavior can change dramatically at interfaces, and these changes become even more pronounced when molecules are confined within nanoscale dimensions. In living organisms, nanoscale channels play a crucial role in selectively transporting molecul ...

The specific and covalent labeling of the protein HaloTag with fluorescent probes in living cells makes it a powerful tool for bioimaging. However, the irreversible attachment of the probe to HaloTag precludes imaging applications that require transient bi ...

To date, the feasibility of super-resolution microscopy for imaging live and thick samples is still limited. Stimulated emission depletion (STED) microscopy requires high-intensity illumination to achieve sub-diffraction resolution, potentially introducing ...

Our understanding of the composition and functions of splenic stromal cells remains incomplete. Here, based on analysis of over 20,000 single cell transcriptomes of splenic fibroblasts, we characterized the phenotypic and functional heterogeneity of these ...

Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transc ...

Dissecting the mechanisms of centriole stability in Caenorhabditis elegans: Focus on SAS-1

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Optical tweeze-sectioning microscopy for 3D imaging and manipulation of suspended cells

Intelligent and Self-Driving Microscopy of Protein Aggregation in Neurodegenerative Diseases

Unravelling the Mesp1/2 Shared Regulatory Landscape - Insights into Developmental Gene Regulation by Using Gastruloids

Deciphering the role of signalling centers in limb development and regeneration

Optical imaging of molecules and their dynamics from surfaces to nanoscale confinement

Using optogenetics to dissect the signals maintaining the DNA damage checkpoint

Exchangeable HaloTag Ligands for Super-Resolution Fluorescence Microscopy

Focus image scanning microscopy for sharp and gentle super-resolved microscopy

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Investigating genetic drivers of disease progression in invasive lobular carcinoma