Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

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Tracking hyperpolarized (HP) ¹³C labeling from either [1-¹³C] pyruvate or [1-¹³C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1-¹³C] pyruvate and [1-¹³C] l ...

Cellular function and behavior are governed not only by molecular composition but also by a cell's native environmental context. By leveraging in-depth molecular quantification and high-resolution imaging methods to study microenvironmental composition and ...

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

Alzheimer's disease (AD) is becoming increasingly prevalent worldwide. It represents one of the greatest medical challenges as no pharmacologic treatments are available to prevent disease progression. Astrocytes play crucial functions within neuronal circu ...

Purpose: Studies at 3T have shown that T-1 relaxometry enables characterization of brain tissues at the single-subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T-1 values at 7T is introduce ...

Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

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Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Computational approaches for spatialomics data: construction, integration and analysis of biomolecular atlases

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Asparagine protects pericentral hepatocytes during acute liver injury

Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease

Submillimeter T-1 atlas for subject-specific abnormality detection at 7T