Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein

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Protein post-translational modifications (PTMs) play a crucial role in countless biological processes, profoundly modulating protein properties on both spatial and temporal scales. Protein PTMs have also emerged as reliable biomarkers for several diseases. ...

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Converging evidence points to the N-terminal domain comprising the first 17 amino acids of the Huntingtin protein (Nt17) as a key regulator of its aggregation, cellular properties and toxicity. In this study, we further investigated the interplay between N ...

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Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein

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