Publication

Degeneration of the intervertebral discs : Effects of Mechanical Stress on Intervertebral Disc Cells ; Selection of a Cell Carrier for the In Vivo Delivery of Fetal Spine Cells

2008
Student Projects

Abstract

[...] Low back pain affects nearly 80% the population at least once in their lifetime. Intervertebral disc (IVD) degeneration is thought to play a role in the development and onset of low back pain. The center part of the disc, the nucleus pulposus (NP), which supports high compressive loads daily, shows early signs of degeneration, long before the outer part of the disc, the annulus fibrosus (AF) degenerates. This work is divided into two parts: the first part focuses on the biomechanics of IVD cells in response to cyclic loading, whereas the second part focuses on the selection of a cell carrier for the further in vivo delivery of fetal spine cells to induce disc regeneration [... click on "Download fulltext" for full abstract]

Official source

https://infoscience.epfl.ch/entities/publication/e3ae62ee-18fc-4111-8e97-779c951aea71

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2008
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/e3ae62ee-18fc-4111-8e97-779c951aea71

About this result

Related concepts (31)

Degenerative disc disease

Degenerative disc disease (DDD) is a medical condition typically brought on by the normal aging process in which there are anatomic changes and possibly a loss of function of one or more intervertebral discs of the spine. DDD can take place with or without symptoms, but is typically identified once symptoms arise. The root cause is thought to be loss of soluble proteins within the fluid contained in the disc with resultant reduction of the oncotic pressure, which in turn causes loss of fluid volume.

Back pain

Back pain is pain felt in the back. It may be classified as neck pain (cervical), middle back pain (thoracic), lower back pain (lumbar) or coccydynia (tailbone or sacral pain) based on the segment affected. The lumbar area is the most common area affected. An episode of back pain may be acute, subacute or chronic depending on the duration. The pain may be characterized as a dull ache, shooting or piercing pain or a burning sensation. Discomfort can radiate to the arms and hands as well as the legs or feet, and may include numbness or weakness in the legs and arms.

Spinal disc herniation

A spinal disc herniation is an injury to the cushioning and connective tissue between vertebrae, usually caused by excessive strain or trauma to the spine. It may result in back pain, pain or sensation in different parts of the body, and physical disability. The most conclusive diagnostic tool for disc herniation is MRI, and treatment may range from painkillers to surgery. Protection from disc herniation is best provided by core strength and an awareness of body mechanics including posture.