Publication

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Related publications (24)

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Patrick Aebischer, Jean-Charles Bensadoun, Bernard Schneider

Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Mechanisms of spindle positioning: cortical force generators in the limelight

Pierre Gönczy, Sachin Kotak

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus plays a crucial role in the partitioning of fate determinants and the disposition of daughter cells in a tissue. Converging evidence indicates that spindle positioning ...

2013

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Philippe Renaud, Anja Kunze, Robert Meissner, Serena Brando

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

2011

Coupling of cortical dynein and Galpha proteins mediates spindle positioning in Caenorhabditis elegans

Pierre Gönczy

Despite being essential for spatial cell division control, the mechanisms governing spindle positioning remain incompletely understood. In the Caenorhabditis elegans one-cell stage embryo, the spindle becomes asymmetrically positioned during anaphase throu ...

2007