Publication

Specific Emotion Regulation Strategies Are Transdiagnostically Associated with Hippocampal Connectivity Markers of Vulnerability to Emotion Dysregulation

2026

Abstract

Emotion dysregulation (ED) is a core transdiagnostic feature of multiple psychiatric conditions and a key marker of vulnerability in high-risk populations, such as the offspring of patients with emotion dysregulation disorders (EDD; e.g., bipolar disorder, borderline personality disorder, attention-deficit/hyperactivity disorder). The hippocampus, central to integrating affective, cognitive, and sensorimotor processes, shows altered dynamic functional connectivity (dFC) in both EDD patients and their unaffected offspring. Building on our previous characterization of hippocampal dFC patterns using micro-coactivation patterns (μCAPs) in this cohort, the present study explored the relationship between these hippocampal connectivity patterns with specific cognitive emotion regulation strategies. We applied Partial Least Squares Correlation (PLS-C) to identify multivariate associations between hippocampal dFC and Cognitive Emotion Regulation Questionnaire (CERQ) scores in 201 participants (74 EDD patients, 57 offspring of EDD patients, and 70 healthy controls). One significant transdiagnostic latent component emerged ( p adj = 0.03), linking higher use of non-adaptive strategies (e.g., self-blame, rumination) to increased hippocampal dFC with the limbic and default mode networks, and greater reliance on adaptive strategies (e.g., positive reappraisal, putting into perspective) to hippocampal dFC with the sensorimotor network, a connectivity profile previously associated with resilience to ED. These associations did not differ significantly between diagnostic groups, underscoring their transdiagnostic relevance. By integrating hippocampal connectivity markers with detailed behavioral profiling, this study highlights specific cognitive strategies as potential modifiable targets for prevention and early intervention in individuals at risk for EDD, including the unaffected offspring of EDD patients.

Official source

https://infoscience.epfl.ch/entities/publication/e209f0e0-ee4a-44bf-9fc2-c262fe165d8a

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/e209f0e0-ee4a-44bf-9fc2-c262fe165d8a

About this result

Related concepts (32)

Emotional self-regulation

Emotional self-regulation or emotion regulation is the ability to respond to the ongoing demands of experience with the range of emotions in a manner that is socially tolerable and sufficiently flexible to permit spontaneous reactions as well as the ability to delay spontaneous reactions as needed. It can also be defined as extrinsic and intrinsic processes responsible for monitoring, evaluating, and modifying emotional reactions.

Default mode network

In neuroscience, the default mode network (DMN), also known as the default network, default state network, or anatomically the medial frontoparietal network (M-FPN), is a large-scale brain network primarily composed of the dorsal medial prefrontal cortex, posterior cingulate cortex, precuneus and angular gyrus. It is best known for being active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering.

Borderline personality disorder

Borderline personality disorder (BPD), also known as emotionally unstable personality disorder (EUPD), is a personality disorder characterized by a long-term pattern of intense and unstable interpersonal relationships, distorted sense of self, and strong emotional reactions. Those affected often engage in self-harm and other dangerous behaviors, often due to their difficulty with returning their emotional level to a healthy or normal baseline. They may also struggle with a feeling of emptiness, fear of abandonment, and dissociation.

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Specific Emotion Regulation Strategies Are Transdiagnostically Associated with Hippocampal Connectivity Markers of Vulnerability to Emotion Dysregulation

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