Publication

Niclosamide: CRL4<sup>AMBRA1</sup> mediated degradation of cyclin D1 following mitochondrial membrane depolarization

Nicolas Thomä
2025

Abstract

Niclosamide, an FDA-approved anthelmintic drug, known to uncouple the mitochondria induces cyclin D1 degradation via CRL4 AMBRA1 . We find a striking correlation between the two processes and that it is observed amongst various compounds.

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