Publication

Oligomerization of activated D- and L-guanosine mononucleotides on templates containing D- and L-deoxycytidylate residues

1998
Journal Articles

Abstract

The oligomerization of activated D- and L- and racemic guanosine-5'-phosphoro-2-methylimidazole on short templates contg. D- and L-deoxycytidylate has been studied. Results obtained with D-oligo(dC)s as templates are similar to those previously reported for expts. with a poly(C) template. When one L-dC or two consecutive L-dCs are introduced into a D-template, regiospecific synthesis of 3'-5' oligo(G)s proceeds to the end of the template, but three consecutive L-dCs block synthesis. Alternating D-,L-oligomers do not facilitate oligomerization of the D-, L-, and racemic 2-guanosine-5'-phosphoro-2-methylimidazole. We suggest that once a "predominately D-metab." existed, occasional L-residues in a temp. would not have led to the termination of self-replication. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/e07238e4-b6c5-4a05-a7a0-4c93300a9d73

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1998
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/e07238e4-b6c5-4a05-a7a0-4c93300a9d73

About this result

Related concepts (19)

Self-replication

Self-replication is any behavior of a dynamical system that yields construction of an identical or similar copy of itself. Biological cells, given suitable environments, reproduce by cell division. During cell division, DNA is replicated and can be transmitted to offspring during reproduction. Biological viruses can replicate, but only by commandeering the reproductive machinery of cells through a process of infection. Harmful prion proteins can replicate by converting normal proteins into rogue forms.

Self-replicating machine

A self-replicating machine is a type of autonomous robot that is capable of reproducing itself autonomously using raw materials found in the environment, thus exhibiting self-replication in a way analogous to that found in nature. The concept of self-replicating machines has been advanced and examined by Homer Jacobson, Edward F. Moore, Freeman Dyson, John von Neumann, Konrad Zuse and in more recent times by K.

Template metaprogramming

Template metaprogramming (TMP) is a metaprogramming technique in which templates are used by a compiler to generate temporary source code, which is merged by the compiler with the rest of the source code and then compiled. The output of these templates can include compile-time constants, data structures, and complete functions. The use of templates can be thought of as compile-time polymorphism. The technique is used by a number of languages, the best-known being C++, but also Curl, D, Nim, and XL.

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Oligomerization of activated D- and L-guanosine mononucleotides on templates containing D- and L-deoxycytidylate residues

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