Publication

Fast detection of single nanoparticles in a microfluidic channel by a microlens array in combination with a conventional optical microscope

Martinus Adela Maria Gijs
2015
Conference Papers

Abstract

We present the use of a microlens array in combination with a conventional optical microscope set-up for the detection of single nanoparticles (NPs) in fluid medium. Optically transparent dielectric microspheres are patterned in a microfabricated well array template and used as microlenses focusing the light originating from a microscope objective into so-called photonic nanojets that expose the medium within the microfluidic channel. When the NPs pass the nanojets, the detection signal is highly enhanced, Au NPs with size down to 50 nm, fluorescent NPs down to 20 nm in size, as well as biomolecule-linked NPs are clearly observed.

Official source

https://infoscience.epfl.ch/entities/publication/dff1b9d3-eb6e-4343-a6ef-eb9b401dab64

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Martinus Adela Maria Gijs
2015
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/dff1b9d3-eb6e-4343-a6ef-eb9b401dab64

About this result

Related concepts (29)

Optical microscope

The optical microscope, also referred to as a light microscope, is a type of microscope that commonly uses visible light and a system of lenses to generate magnified images of small objects. Optical microscopes are the oldest design of microscope and were possibly invented in their present compound form in the 17th century. Basic optical microscopes can be very simple, although many complex designs aim to improve resolution and sample contrast. The object is placed on a stage and may be directly viewed through one or two eyepieces on the microscope.

Near-field scanning optical microscope

Near-field scanning optical microscopy (NSOM) or scanning near-field optical microscopy (SNOM) is a microscopy technique for nanostructure investigation that breaks the far field resolution limit by exploiting the properties of evanescent waves. In SNOM, the excitation laser light is focused through an aperture with a diameter smaller than the excitation wavelength, resulting in an evanescent field (or near-field) on the far side of the aperture.

Confocal microscopy

Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a sample enables the reconstruction of three-dimensional structures (a process known as optical sectioning) within an object.

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Fast detection of single nanoparticles in a microfluidic channel by a microlens array in combination with a conventional optical microscope

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