Publication

Conjugates of photosensitizers and oligonucleotides for selective photochemiotherapy

2004
Patents

Abstract

This invention relates to oligonucleotide targeting agents and their use in the treatment of diseased cells by selective photochemotherapy (PCT). PCT is a method of treating human diseases and disorders, bacteriological indications and other pathological conditions. PCT is based on the topical or systemic application of a photosensitizing agent, a precursor or pro-drug thereof, which preferentially accumulates in the target tissue. Irradiation of the photosensitizing agent located in the target. tissue with electromagnetic radiation of an appropriate wavelength and the interaction of the thus excited photosensitive moiety with oxygen leads to tissue damage and destruction of the irradiated areas.

Official source

https://infoscience.epfl.ch/entities/publication/dfb92472-fffc-4295-be85-5b5274ffdd1e

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2004
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/dfb92472-fffc-4295-be85-5b5274ffdd1e

About this result

Related concepts (32)

Photodynamic therapy

Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT is popularly used in treating acne. It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. It also treats malignant cancers including head and neck, lung, bladder and particular skin.

Photosensitizer

Photosensitizers are light absorbers that alters the course of a photochemical reaction. They usually are catalysts. They can function by many mechanisms, sometimes they donate an electron to the substrate, sometimes they abstract a hydrogen atom from the substrate. At the end of this process, the photosensitizer returns to its ground state, where it remains chemically intact, poised to absorb more light. One branch of chemistry which frequently utilizes photosensitizers is polymer chemistry, using photosensitizers in reactions such as photopolymerization, photocrosslinking, and photodegradation.

Irradiation

Irradiation is the process by which an object is exposed to radiation. An irradiator is a device used to expose an object to radiation, notably gamma radiation, for a variety of purposes. Irradiators may be used for sterilizing medical and pharmaceutical supplies, preserving foodstuffs, alteration of gemstone colors, studying radiation effects, eradicating insects through sterile male release programs, or calibrating thermoluminescent dosimeters (TLDs). The exposure can originate from various sources, including natural sources.

Related publications (23)

Conjugates of photosensitizers and oligonucleotides for selective photochemiotherapy

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