Publication

The maternal gut–fetal brain axis: role of maternal microbial metabolome in early neurodevelopment

2026

Abstract

Fetal neurodevelopment is a critical phase modulated by the maternal microbiome. While certain specific signaling pathways have been identified, the complete signaling network and the spatial and temporal complexity remain largely unknown. Maternal metabolites are essential for fetal growth and certain metabolites are subject to dynamic adaptation during pregnancy. Alteration of maternal microbe richness and diversity, caused by malnutrition, psycho-social distress, and or infection, are cues known to impair fetal neural developmental circuits concomitant with increased risk of cognitive dysfunction later in life. This mini review focuses on the role of maternal microbial metabolites in shaping fetal neurodevelopment.

Official source

https://infoscience.epfl.ch/entities/publication/dc2d8d18-61b8-44fb-bb8d-70ca54d68299

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/dc2d8d18-61b8-44fb-bb8d-70ca54d68299

About this result

Related concepts (32)

Development of the nervous system in humans

The development of the nervous system in humans, or neural development or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience to describe the cellular and molecular mechanisms by which the complex nervous system forms in humans, develops during prenatal development, and continues to develop postnatally.

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The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

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In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Signals that originate from outside a cell (or extracellular signals) can be physical agents like mechanical pressure, voltage, temperature, light, or chemical signals (e.g., small molecules, peptides, or gas).

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The maternal gut–fetal brain axis: role of maternal microbial metabolome in early neurodevelopment

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