The Mind Behind the Hebbian Synapse Donald O Hebb

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LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Maria del Carmen Sandi Perez, Olivia Zanoletti, Alexandre Claude Gustave Bacq

The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be invol ...

2020

Dendritic Voltage Recordings Explain Paradoxical Synaptic Plasticity: A Modeling Study

Laureline Logiaco, Wulfram Gerstner

Experiments have shown that the same stimulation pattern that causes Long-Term Potentiation in proximal synapses, will induce Long-Term Depression in distal ones. In order to understand these, and other, surprising observations we use a phenomenological mo ...

FRONTIERS RESEARCH FOUNDATION2020

Music enhances structural maturation of emotional processing neural pathways in very preterm infants

François Lazeyras, Nicolas Kunz

Prematurity disrupts brain maturation by exposing the developing brain to different noxious stimuli present in the neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of brain development, leading to ...

2020

Brain functional connectivity dynamics at rest in the aftermath of affective and cognitive challenges

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Gwladys Rey

Carry-over effects on brain states have been reported following emotional and cognitive events, persisting even during subsequent rest. Here, we investigated such effects by identifying recurring co-activation patterns (CAPs) in neural networks at rest wit ...

Wiley2020

Training Algorithms for Multiple Object Tracking

Andrii Maksai

Multiple object tracking is a crucial Computer Vision Task. It aims at locating objects of interest in the image sequences, maintaining their identities, and identifying their trajectories over time. A large portion of current research focuses on tracking ...

EPFL2019

Optimal Stimulation Protocol in a Bistable Synaptic Consolidation Model

Wulfram Gerstner, Chiara Gastaldi, Samuel Pavio Muscinelli

Synaptic changes induced by neural activity need to be consolidated to maintain memory over a timescale of hours. In experiments, synaptic consolidation can be induced by repeating a stimulation protocol several times and the effectiveness of consolidation ...

2019

The Deformation Capacity of Lap Splices in RC Walls: From Experimental Testing to Numerical Modelling

Danilo Tarquini

Field observations as well as experimental tests have shown that both the strength and displacement capacity of reinforced concrete (RC) members might be significantly reduced by the presence of lap splices. This degradation applies in particular if the lo ...

EPFL2019

Synthesis and Characterization of Coordination Cages Based on Clathrochelate Metalloligands

Giacomo Cecot

The work presented in this thesis focused on the synthesis and characterization of new metalloligands based on iron(II) clathrochelate complexes. Clathrochelates can be functionalized peripherally with donor groups capable of coordinating metal ions. The s ...

EPFL2019

Statistical Applications of Random Matrix Theory: Comparison of Two Populations

Rémy Mariétan

During the last twenty years, Random matrix theory (RMT) has produced numerous results that allow a better understanding of large random matrices. These advances have enabled interesting applications in the domain of communication. Although this theory can ...

EPFL2019

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

Pierre Magistretti

A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memo ...

Nature Publishing Group2015