Publication

Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

Qian Wang, Jieping Zhu, Hua Wu
2020
Journal Articles

Abstract

We report herein the first examples of a palladiumcatalyzed enantioselective Cacchi reaction for the synthesis of indoles bearing a chiral C2-aryl axis. In the presence of a catalytic amount of Pd(OAc)2 and (R,R)-QuinoxP* ligand, reaction of N-aryl(alkyl)sulfonyl-2-alkynylanilides with arylboronic acids under oxygen atmosphere afforded enantioenriched 2,3-disubstituted indoles in high yields and enantioselectivity. The indole ring is constructed de novo in this process and a complexation-induced chirality transfer is proposed to account for the observed enantioselectivity.

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https://infoscience.epfl.ch/entities/publication/da5037c3-445c-4b02-bad1-e2dff147f2e8

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Qian Wang, Jieping Zhu, Hua Wu
2020
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/da5037c3-445c-4b02-bad1-e2dff147f2e8

About this result

Related concepts (32)

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Palladium-Catalyzed Enantioselective Cacchi Reaction: Asymmetric Synthesis of Axially Chiral 2,3-Disubstituted Indoles

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