Study of disease-associated proteins using integrative structural biology: the case of GOLPH3 and PREPL

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The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Maurizio Molinari

Organellophagy receptors control the generation and delivery of portions of their homing organelle to acidic degradative compartments to recycle nutrients, remove toxic or aged macromolecules and remodel the organelle upon physiologic or pathologic cues. H ...

2025

Editorial: Regional and molecular fingerprint of adipogenesis in aging and disease

Josefine Catharina Pedersen Tratwal

FRONTIERS MEDIA SA2023

Model biomolecular condensates have heterogeneous structure quantitatively dependent on the interaction profile of their constituent macromolecules

Julian Charles Shillcock

Biomolecular condensates play numerous roles in cells by selectively concentrating client proteins while excluding others. These functions are likely to be sensitive to the spatial organization of the scaffold proteins forming the condensate. We use coarse ...

2022

Three-Dimensional Confinement of Water: H2O Exhibits Long-Range (> 50 nm) Structure while D2O Does Not

Sylvie Roke, Nathan Dupertuis, Cornelis Ulrich Lütgebaucks, Orly Bagunu Tarun

Water is the liquid of life thanks to its three-dimensional adaptive hydrogen (H)-bond network. Confinement of this network may lead to dramatic structural changes influencing chemical and physical transformations. Although confinement effects occur on a < ...

AMER CHEMICAL SOC2022