Publication

All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

Urs von Stockar, Christopher Cannizzaro, Martin Rhiel
2000
Conference Papers

Abstract

Comprehensive and cGMP suitable bioprocess monitoring is still a challenge in microbial fermn. and cell culture process development. This paper discusses the exploitation of in-situ mid-IR spectroscopy in combination with partial least-squares anal. to monitor carbohydrate, amino acid, org. acid, pH, temp., and biomass content of Saccharomyces Cerevisiae, Phaffia rhodozyma, and CHO cell cultures. Reliability of the monitored values will be discussed for potential application in cGMP environments along with case studies to increase the productivity by using the information for controlling the processes. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/da08e807-cbaf-48d1-b416-b84c0d776a0a

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Urs von Stockar, Christopher Cannizzaro, Martin Rhiel
2000
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/da08e807-cbaf-48d1-b416-b84c0d776a0a

About this result

Related concepts (27)

Cell culture

Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. This technique is also called micropropagation. After the cells of interest have been isolated from living tissue, they can subsequently be maintained under carefully controlled conditions. They need to be kept at body temperature (37 °C) in an incubator.

Biomass (energy)

Biomass, in the context of energy production, is matter from recently living (but now dead) organisms which is used for bioenergy production. Examples include wood, wood residues, energy crops, agricultural residues including straw, and organic waste from industry and households. Wood and wood residues is the largest biomass energy source today. Wood can be used as a fuel directly or processed into pellet fuel or other forms of fuels. Other plants can also be used as fuel, for instance maize, switchgrass, miscanthus and bamboo.

Energy crop

Energy crops are low-cost and low-maintenance crops grown solely for renewable bioenergy production (not for food). The crops are processed into solid, liquid or gaseous fuels, such as pellets, bioethanol or biogas. The fuels are burned to generate electrical power or heat. The plants are generally categorized as woody or herbaceous. Woody plants include willow and poplar, herbaceous plants include Miscanthus x giganteus and Pennisetum purpureum (both known as elephant grass).

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All-in-one bioprocess monitoring with a mid-IR spectroscopic sensor

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