Publication

A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer

Christian Iseli
2023
Journal Articles

Abstract

We have previously shown that vaccination with tumor-pulsed dendritic cells amplifies neoantigen recognition in ovarian cancer. Here, in a phase 1 clinical study (NCT01312376/UPCC26810) including 19 patients, we show that such responses are further reinvigorated by subsequent adoptive transfer of vaccine-primed, ex vivo-expanded autologous peripheral blood T cells. The treatment is safe, and epitope spreading with novel neopeptide reactivities was observed after cell infusion in patients who experienced clinical benefit, suggesting reinvigoration of tumor-sculpting immunity.

Official source

https://infoscience.epfl.ch/entities/publication/d98367be-3ef9-4f50-a339-e63658645fc5

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