Publication

The cGAS-STING pathway: Mechanism and medical implications

2026

Abstract

The cGAS-STING pathway is a central mechanism of innate immunity that detects double-stranded DNA and translates it into transcriptional and other cellular effector responses. Beyond its canonical role in antiviral defense, the pathway senses diverse endogenous DNA species generated as byproducts during various contexts of cell stress. In this capacity, cGAS-STING impacts tissue homeostasis and antitumor immunity, but it is also associated with a number of inflammatory disorders. Here, we review the mechanisms, physiological functions, and disease implications of cGAS-STING signaling and discuss how its context-dependent biology informs emerging therapeutic strategies.

Official source

https://infoscience.epfl.ch/entities/publication/d8690266-4659-4a54-97e3-eccece506420

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/d8690266-4659-4a54-97e3-eccece506420

About this result

Related concepts (31)

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

Related publications (11)

The cGAS-STING pathway: Mechanism and medical implications

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