Publication

Applications of magnetic Labs-on-a-chip

Martinus Adela Maria Gijs
2010
Book Chapters

Abstract

Using magnetic micro- and nanoparticles (beads) in microfluidic chips opens new perspectives for miniaturized applications in analytical sciences. Four important application areas of magnetic particles in microfluidic systems are discussed. The first one is that of manipulation of living cells. The latter can be labeled using magnetic beads that are specifically recognizing certain biomarkers on the cell surface. In this way, a well determined type of cells can be separated out of a complex matrix. Magnetic particles can also be used as substrates in a nucleic acid assay allowing specific detection and application in diagnosis. Immuno-assays represent another vast area of application for magnetic particles. The latter can either be used as mobile substrate in the assay, or the particle can play the role of magnetic detection label. Finally, a last field of application we discuss is the use of magnetic particles held in a microfluidic flow for catalytic applications.

Official source

https://infoscience.epfl.ch/entities/publication/d763c0f1-7f02-47e2-a484-afe4066436e6

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Martinus Adela Maria Gijs
2010
Book Chapters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/d763c0f1-7f02-47e2-a484-afe4066436e6

About this result

Related concepts (32)

Microfluidics

Microfluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.

Droplet-based microfluidics

Droplet-based microfluidics manipulate discrete volumes of fluids in immiscible phases with low Reynolds number and laminar flow regimes. Interest in droplet-based microfluidics systems has been growing substantially in past decades. Microdroplets offer the feasibility of handling miniature volumes (μl to fl) of fluids conveniently, provide better mixing, encapsulation, sorting, sensing and are suitable for high throughput experiments.

Paper-based microfluidics

Paper-based microfluidics are microfluidic devices that consist of a series of hydrophilic cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to a desired outlet or region of the device, by means of capillary action. This technology builds on the conventional lateral flow test which is capable of detecting many infectious agents and chemical contaminants. The main advantage of this is that it is largely a passively controlled device unlike more complex microfluidic devices.

Related publications (22)

Applications of magnetic Labs-on-a-chip

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