Antimalarial medicationAntimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young children and pregnant women. As of 2018, modern treatments, including for severe malaria, continued to depend on therapies deriving historically from quinine and artesunate, both parenteral (injectable) drugs, expanding from there into the many classes of available modern drugs.
Window managerA window manager is system software that controls the placement and appearance of windows within a windowing system in a graphical user interface. Most window managers are designed to help provide a desktop environment. They work in conjunction with the underlying graphical system that provides required functionality—support for graphics hardware, pointing devices, and a keyboard—and are often written and created using a widget toolkit. Few window managers are designed with a clear distinction between the windowing system and the window manager.
Tiling window managerIn computing, a tiling window manager is a window manager with an organization of the screen into mutually non-overlapping frames, as opposed to the more common approach (used by stacking window managers) of coordinate-based stacking of overlapping objects (windows) that tries to fully emulate the desktop metaphor. The first Xerox Star system (released in 1981) tiled application windows, but allowed dialogs and property windows to overlap. Later, Xerox PARC also developed CEDAR (released in 1982), the first windowing system using a tiled window manager.
Windowing systemIn computing, a windowing system (or window system) is a software suite that manages separately different parts of display screens. It is a type of graphical user interface (GUI) which implements the WIMP (windows, icons, menus, pointer) paradigm for a user interface. Each currently running application is assigned a usually resizable and usually rectangular surface of the display to present its GUI to the user; these windows may overlap each other, as opposed to a tiling interface where they are not allowed to overlap.
Climate change denialClimate change denial or global warming denial is dismissal or unwarranted doubt that contradicts the scientific consensus on climate change. Those promoting denial commonly use rhetorical tactics to give the appearance of a scientific controversy where there is none. Climate change denial includes doubts to the extent of how much climate change is caused by humans, its effects on nature and human society, and the potential of adaptation to global warming by human actions.
Plasmodium falciparumPlasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria. It is responsible for around 50% of all malaria cases. P. falciparum is therefore regarded as the deadliest parasite in humans. It is also associated with the development of blood cancer (Burkitt's lymphoma) and is classified as a Group 2A (probable) carcinogen.
QuinineQuinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. It can be taken by mouth or intravenously. Malaria resistance to quinine occurs in certain areas of the world. Quinine is also used as an ingredient in tonic water to impart a bitter taste.
X Window SystemThe X Window System (X11, or simply X) is a windowing system for bitmap displays, common on Unix-like operating systems. X provides the basic framework for a GUI environment: drawing and moving windows on the display device and interacting with a mouse and keyboard. X does not mandate the user interface - this is handled by individual programs. As such, the visual styling of X-based environments varies greatly; different programs may present radically different interfaces.
Climate changeIn common usage, climate change describes global warming—the ongoing increase in global average temperature—and its effects on Earth's climate system. Climate change in a broader sense also includes previous long-term changes to Earth's climate. The current rise in global average temperature is more rapid than previous changes, and is primarily caused by humans burning fossil fuels. Fossil fuel use, deforestation, and some agricultural and industrial practices increase greenhouse gases, notably carbon dioxide and methane.
ArtemisininArtemisinin (ˌɑːtɪˈmiːsɪnɪn) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) are now standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin is extracted from the plant Artemisia annua, sweet wormwood, a herb employed in Chinese traditional medicine.
Compositing window managerA compositing manager, or compositor, is software that provides applications with an off-screen buffer for each window. The compositing manager composites the window buffers into an image representing the screen and writes the result into the display memory. A compositing window manager is a window manager that is also a compositing manager. Compositing managers may perform additional processing on buffered windows, applying 2D and 3D animated effects such as blending, fading, , rotation, duplication, bending and contortion, shuffling, blurring, redirecting applications, and translating windows into one of a number of displays and virtual desktops.
Politics of climate changeThe politics of climate change results from different perspectives on how to respond to climate change. Global warming is driven largely by the emissions of greenhouse gases due to human economic activity, especially the burning of fossil fuels, certain industries like cement and steel production, and land use for agriculture and forestry. Since the Industrial Revolution, fossil fuels have provided the main source of energy for economic and technological development.
History of malariaThe history of malaria extends from its prehistoric origin as a zoonotic disease in the primates of Africa through to the 21st century. A widespread and potentially lethal human infectious disease, at its peak malaria infested every continent except Antarctica. Its prevention and treatment have been targeted in science and medicine for hundreds of years. Since the discovery of the Plasmodium parasites which cause it, research attention has focused on their biology as well as that of the mosquitoes which transmit the parasites.
Antimicrobial resistanceAntimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials (drugs used to treat infections). All classes of microbes can evolve resistance where the drugs are no longer effective. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. Protozoa evolve antiprotozoal resistance, and bacteria evolve antibiotic resistance. Together all of these come under the umbrella of antimicrobial resistance.
Media coverage of climate changeMedia coverage of climate change has had effects on public opinion on climate change, as it conveys the scientific consensus on climate change that the global temperature has increased in recent decades and that the trend is caused by human-induced emissions of greenhouse gases. Climate change communication research shows that coverage has grown and become more accurate. Some researchers and journalists believe that media coverage of politics of climate change is adequate and fair, while a few feel that it is biased.
Climate change adaptationClimate change adaptation is the process of adjusting to the effects of climate change. These can be both current or expected impacts. Adaptation aims to moderate or avoid harm for people. It also aims to exploit opportunities. Humans may also intervene to help adjustment for natural systems. There are many adaptation strategies or options.They can help manage impacts and risks to people and nature. We can classify adaptation actions in four ways. These are infrastructural and technological; institutional; behavioural and cultural; and nature-based options.
Drug discoveryIn the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology.
