Publications related to Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

Related publications (6)

Trajectories of macrophage ontogeny and reprogramming in cancer

Mehdi Louis Hicham, Michele De Palma, Nahal Mansouri, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Florent Philippe Maurice Duval, Céline Wyser Rmili

Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

2025

Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics

Dario Neri

Antibody-Drug Conjugates (ADCs) are one of the most diffused targeted therapeutic modalities for cancer treatment and consist of a tumor-targeted monoclonal antibody connected to a cytotoxic payload, which is released selectively at the tumor site. Small M ...

American Association for Cancer Research (AACR)2025

Leveraging chromatin modules to explore the impact of regulatory variation on disease

Olga Pushkarev

Human genome is complex and hierarchically organized within the nucleus, where cis-regulatory elements (CREs) frequently interact within topologically associated domains to regulate gene expression. While genomic technologies and computational approaches h ...

EPFL2025

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

Andrew Charles Oates, Sundar Ram Naganathan, Daniele Soroldoni, Laurel Ann Rohde, Petr Strnad, Arianne Bercowsky Rama, Guillaume Michel Valentin

Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

2024

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

Ingrid Maria van Mier

Breast cancer is the most common cancer in women worldwide, with an estimated 1.7 million newly diagnosed cases in 2012. Despite the many clinical manifestations, metastatic disease is the main cause of death, and is responsible for 90% of all breast cance ...

EPFL2017

Platinum nanopetal-based potassium sensors for acute cell death monitoring

Giovanni De Micheli, Sandro Carrara, Irene Taurino

Growing interest in the role of ions as cell death regulators has led to the consideration of K+, which plays a major role in events such as necrosis, apoptosis and osmotic shock. These mechanisms induce effluxes of K+, which can be m ...

RSC Publishing2016