Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

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Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

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Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

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Trajectories of macrophage ontogeny and reprogramming in cancer

Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

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Platinum nanopetal-based potassium sensors for acute cell death monitoring