Publication

New Tools in Bio-NMR: Indirect Detection of Nitrogen-14 in Solids

2010
Journal Articles

Abstract

This paper presents an overview of recently developed methods for the indirect detection of N-14 nuclei (spin I = 1) in spinning solids by nuclear magnetic resonance spectroscopy. These methods exploit the transfer of coherence from a neighboring 'spy' nucleus with spin S = (1)/(2), such as 130 or H-1, to single- or double-quantum transitions of 14N nuclei. The two-dimensional correlation methods presented here are closely related to the well-known heteronuclear single- and multiple-quantum correlation (HSQC and HMQC, respectively) experiments, already widely used for the investigation of molecules in liquids. Nitrogen-14 NMR spectra exhibit powder patterns characterized by second- and third-order quadrupolar couplings which can provide important information about structure and dynamics of molecules in powder samples.

Official source

https://infoscience.epfl.ch/entities/publication/d0413527-9b74-4956-801d-cc718df724d3

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2010
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/d0413527-9b74-4956-801d-cc718df724d3

About this result

Related concepts (32)

Nuclear magnetic resonance spectroscopy of proteins

Nuclear magnetic resonance spectroscopy of proteins (usually abbreviated protein NMR) is a field of structural biology in which NMR spectroscopy is used to obtain information about the structure and dynamics of proteins, and also nucleic acids, and their complexes. The field was pioneered by Richard R. Ernst and Kurt Wüthrich at the ETH, and by Ad Bax, Marius Clore, Angela Gronenborn at the NIH, and Gerhard Wagner at Harvard University, among others.

Nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. This spectroscopy is based on the measurement of absorption of electromagnetic radiations in the radio frequency region from roughly 4 to 900 MHz. Absorption of radio waves in the presence of magnetic field is accompanied by a special type of nuclear transition, and for this reason, such type of spectroscopy is known as Nuclear Magnetic Resonance Spectroscopy.

Nuclear magnetic resonance

Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca.

Related publications (32)

New Tools in Bio-NMR: Indirect Detection of Nitrogen-14 in Solids

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