The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

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Bruton's tyrosine kinase (Btk) is a key component of BCR signaling required for B-cell maturation and activation. Loss-of-function mutations throughout the Btk protein cause human X-linked agammaglobulinemia (XLA), a heritable genetic disorder characterize ...

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Bruton's tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA). In contrast, Btk signaling sustains growth of several B-cell neoplasms which may be treated with ...

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The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

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Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Novel quantitative bioengineered tools to track human bone marrow niche cellular constituents in health and disease

Whole-genome doubling drives oncogenic loss of chromatin segregation

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis

Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Integrative transcriptome analyses of Transposable Elements (TEs) and genes contribute to a better understanding of colorectal cancer

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

Interfacial Water Many-Body Effects Drive Structural Dynamics and Allosteric Interactions in SARS-CoV-2 Main Protease Dimerization Interface

Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci

Notch Signaling - a Booster of Chronic Lymphocytic Leukemia During Initiation and Disease Progression

Allosteric regulation and targeting of Bruton's tyrosine kinase (Btk) in B-cell lymphoma

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

Mechanics and co-evolution of allosteric materials and proteins

Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia

Enhancing the Signaling of GPCRs via Orthosteric Ions

Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro