Gene expressionGene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA.
Flat moduleIn algebra, flat modules include free modules, projective modules, and, over a principal ideal domain, torsion free modules. Formally, a module M over a ring R is flat if taking the tensor product over R with M preserves exact sequences. A module is faithfully flat if taking the tensor product with a sequence produces an exact sequence if and only if the original sequence is exact. Flatness was introduced by in his paper Géometrie Algébrique et Géométrie Analytique.
Protein microarrayA protein microarray (or protein chip) is a high-throughput method used to track the interactions and activities of proteins, and to determine their function, and determining function on a large scale. Its main advantage lies in the fact that large numbers of proteins can be tracked in parallel. The chip consists of a support surface such as a glass slide, nitrocellulose membrane, bead, or microtitre plate, to which an array of capture proteins is bound. Probe molecules, typically labeled with a fluorescent dye, are added to the array.
D-moduleIn mathematics, a D-module is a module over a ring D of differential operators. The major interest of such D-modules is as an approach to the theory of linear partial differential equations. Since around 1970, D-module theory has been built up, mainly as a response to the ideas of Mikio Sato on algebraic analysis, and expanding on the work of Sato and Joseph Bernstein on the Bernstein–Sato polynomial. Early major results were the Kashiwara constructibility theorem and Kashiwara index theorem of Masaki Kashiwara.
Structure theorem for finitely generated modules over a principal ideal domainIn mathematics, in the field of abstract algebra, the structure theorem for finitely generated modules over a principal ideal domain is a generalization of the fundamental theorem of finitely generated abelian groups and roughly states that finitely generated modules over a principal ideal domain (PID) can be uniquely decomposed in much the same way that integers have a prime factorization. The result provides a simple framework to understand various canonical form results for square matrices over fields.
StatisticsStatistics (from German: Statistik, () "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal".
False positive rateIn statistics, when performing multiple comparisons, a false positive ratio (also known as fall-out or false alarm ratio) is the probability of falsely rejecting the null hypothesis for a particular test. The false positive rate is calculated as the ratio between the number of negative events wrongly categorized as positive (false positives) and the total number of actual negative events (regardless of classification). The false positive rate (or "false alarm rate") usually refers to the expectancy of the false positive ratio.
Transcriptomics technologiesTranscriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription. Here, mRNA serves as a transient intermediary molecule in the information network, whilst non-coding RNAs perform additional diverse functions. A transcriptome captures a snapshot in time of the total transcripts present in a cell.
Sample maximum and minimumIn statistics, the sample maximum and sample minimum, also called the largest observation and smallest observation, are the values of the greatest and least elements of a sample. They are basic summary statistics, used in descriptive statistics such as the five-number summary and Bowley's seven-figure summary and the associated box plot. The minimum and the maximum value are the first and last order statistics (often denoted X(1) and X(n) respectively, for a sample size of n).
Statistical assumptionStatistics, like all mathematical disciplines, does not infer valid conclusions from nothing. Inferring interesting conclusions about real statistical populations almost always requires some background assumptions. Those assumptions must be made carefully, because incorrect assumptions can generate wildly inaccurate conclusions. Here are some examples of statistical assumptions: Independence of observations from each other (this assumption is an especially common error). Independence of observational error from potential confounding effects.
Differential operatorIn mathematics, a differential operator is an operator defined as a function of the differentiation operator. It is helpful, as a matter of notation first, to consider differentiation as an abstract operation that accepts a function and returns another function (in the style of a higher-order function in computer science). This article considers mainly linear differential operators, which are the most common type. However, non-linear differential operators also exist, such as the Schwarzian derivative.
Bayesian networkA Bayesian network (also known as a Bayes network, Bayes net, belief network, or decision network) is a probabilistic graphical model that represents a set of variables and their conditional dependencies via a directed acyclic graph (DAG). It is one of several forms of causal notation. Bayesian networks are ideal for taking an event that occurred and predicting the likelihood that any one of several possible known causes was the contributing factor. For example, a Bayesian network could represent the probabilistic relationships between diseases and symptoms.
