Publication

Potential of Guidewire‐Clot Interaction Forces for Clot Detection in Robotic Mechanical Thrombectomy

Mohamed Bouri
2025

Abstract

BackgroundInterventional neuroradiologists currently miss crucial information when facing an ischaemic stroke case as they cannot localise the thrombus precisely nor determine its mechanical properties, which are both important for the clot extraction procedure.MethodsIn this in vitro study, clot analogues of different stiffnesses and dimensions were inserted in an idealised arterial phantom using distinct insertion pressure levels. Guidewire‐clot interaction forces were recorded using a robotic device equipped with a force sensor. A model‐based clot detection method was developed.ResultsClot stiffness, initial clot volume, and insertion pressure were all found to impact the guidewire‐clot interaction forces. In detecting the clot's proximal and distal edges, we achieved success rates of 86.5% and 71.2%, respectively, within a tolerance of 1.5 mm.ConclusionsThe study brings new perspectives for mechanical thrombectomy by demonstrating that multiple parameters influence the occlusion's mechanical state and by proposing algorithms for identifying the clot's extremities.

Official source

https://infoscience.epfl.ch/entities/publication/cab0d9d8-c180-4254-860a-d9a18f76d14e

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Mohamed Bouri
2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/cab0d9d8-c180-4254-860a-d9a18f76d14e

About this result

Related concepts (32)

Stroke

A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly. Signs and symptoms of a stroke may include an inability to move or feel on one side of the body, problems understanding or speaking, dizziness, or loss of vision to one side. Signs and symptoms often appear soon after the stroke has occurred.

Anticoagulant

Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals.

Thrombus

A thrombus (: thrombi), colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis. There are two components to a thrombus: aggregated platelets and red blood cells that form a plug, and a mesh of cross-linked fibrin protein. The substance making up a thrombus is sometimes called cruor. A thrombus is a healthy response to injury intended to stop and prevent further bleeding, but can be harmful in thrombosis, when a clot obstructs blood flow through healthy blood vessels in the circulatory system.