Publication

Across-cities transportable 13C hyperpolarization using UV-induced labile radicals

2026

Abstract

Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging (HP 13C-MRSI) has the potential to transform diagnostic radiology thanks to its unique ability to noninvasively detect a broad range of diseases entailing aberrant metabolism. However, clinical adoption has been hindered by the short lifetime of 13C-hyperpolarization and the resulting need for on-site polarizer near the MR scanner. In this work, we present a solution for long-lived transportable HP molecular contrast agents that uses dissolution Dynamic Nuclear Polarization (dDNP) combined with UV-induced labile radicals. This approach allows centralized pre-polarization and transport under hours-long storage T1 conditions. We validate this concept through the first across-cities HP 13C-MRSI experiments in vivo, injecting healthy female rats with both a perfusion/angiography ([1-13C]HP001) and a metabolic ([U-13C, d7]glucose) contrast agent. Our findings advance the feasibility of decentralized, scalable HP MRI workflows, removing the barrier of on-site infrastructure.

Official source

https://infoscience.epfl.ch/entities/publication/ca25ffd5-cd41-46fb-862b-d8e152f49ba3

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/ca25ffd5-cd41-46fb-862b-d8e152f49ba3

About this result

Related concepts (26)

Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans.

Contrast agent

A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. Contrast agents absorb or alter external electromagnetism or ultrasound, which is different from radiopharmaceuticals, which emit radiation themselves. In x-ray imaging, contrast agents enhance the radiodensity in a target tissue or structure. In magnetic resonance imaging, contrast agents shorten (or in some instances increase) the relaxation times of nuclei within body tissues in order to alter the contrast in the image.

Radiocontrast agent

Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography (contrast CT), projectional radiography, and fluoroscopy. Radiocontrast agents are typically iodine, or more rarely barium sulfate. The contrast agents absorb external X-rays, resulting in decreased exposure on the X-ray detector. This is different from radiopharmaceuticals used in nuclear medicine which emit radiation.

Related publications (1)

Across-cities transportable 13C hyperpolarization using UV-induced labile radicals

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Improvement in the Quantification of Myocardial Perfusion Using an Automatic Spline-Based Registration Algorithm