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A general and practical N-iodosuccinimide (NIS)-promoted aza-Friedel–Crafts reaction of various aromatic nucleophiles with N-acylimines generated in situ from a-amidosulfides to give a rapid access to highly functionalized amines is described. The newly developed methodology is very mild, fast, efficient, and complementary.
Wendy Lee Queen, Ilia Kochetygov, Jordi Espin Marti, Till Marian Schertenleib, Anita Justin, Jocelyn Richard Roth, Nazanin Taheri