Publication

Pathogenic Pore-Forming Proteins: Function and Host Response

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache, Mirko Bischofberger
2012
Reviews

Abstract

Organisms from all kingdoms produce pore-forming proteins, with the best-characterized being of bacterial origin. The last decade of research has revealed that the channels formed by these proteins can be very diverse, thus differentially affecting target cell-membrane permeability and consequent cellular outcome. The responses to these toxins are also extremely diverse due to multiple downstream effects of pore-induced changes in ion balance. Determining the secondary effects of pore-forming toxins is essential to understand their contribution to infection.

Official source

https://infoscience.epfl.ch/entities/publication/c564b2d8-5496-4162-93bb-05b7ec4ebe68

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Pathogenic Pore-Forming Proteins: Function and Host Response

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