ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction

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Living cells operate as thermodynamically open systems, perpetually sustained far from equilibrium by the continuous dissipation of energy. Among the most striking manifestations of this principle is proteostasis: the dynamic maintenance of the cellular pr ...

Cell-to-cell communication is fundamental to multicellular life. In plants, plasmodesmata-cytoplasmic channels that connect adjacent cells-enable the transport of molecules between cells. In roots, such transport is thought to play a central role in nutrie ...

Self-regeneration is a key function of living systems that needs to be recapitulated in vitro to create a living synthetic cell. A major limiting factor for protein self-regeneration in the PURE cell-free transcription-translation system is its high protei ...

Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are produc ...

Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and fibrillar aggregates plays an i ...

Secretory proteins and lipids are biosynthesized in the endoplasmic reticulum (ER). The "protein quality control" system (PQC) monitors glycoprotein folding and supports the elimination of terminally misfolded polypeptides. A key component of the PQC syste ...

Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD(+), but little is known about their contribution to endogenous NAD(+) turnover and muscle plasticity during skeletal muscle growth and remodeling. Usin ...

Hepatocytes compose up to 80% of the total liver and have been indicated as important players in the induction of immunologic tolerance in this organ. We show that hepatocytes possess the molecular machinery required for the cross-presentation of extracell ...

Identifying protein-protein interactions is crucial for a systems-level understanding of the cell. Recently, algorithms based on inverse statistical physics, e.g., direct coupling analysis (DCA), have allowed to use evolutionarily related sequences to addr ...

ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction

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Protein Organisation at Different Scales: Amyloid Disaggregation, Chaperone Networks and Engineered Allostery

A Developmental Switch Controls Cell-to-cell Transport in Roots Via Pectin-linked Plasmodesmata Changes

Towards Self-regeneration: Exploring the Limits of Protein Synthesis in the Protein Synthesis Using Recombinant Elements (PURE) Cell-free Transcription-Translation System

Learning the rules of mitochondrial network dynamics using generative models

Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis

Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases

Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8(+) T Cell Tolerance Development

Statistical physics of interacting proteins: Impact of dataset size and quality assessed in synthetic sequences